We presented a microfluidic 3D co-culture device to reconstruct an resemble in-vivo tumor micro-environment and investigated the role of associated fibroblast (CAF) in tumor invasion. We observed that CAF could promote the tumor spheroid invasion in salivary gland adenoid cystic carcinoma (ACC) significantly, indicating the potential of CAF as a target for cancer therapy.

Lab on a Chip, 2010,10, 1671 – 1677

Rapid Prototyping of Paper Microfluidics with Wax for Portable Bioassay

We proposed a very simple and low-cost method to generate paper-based microfluidic devices with wax for portable bioassay. The wax can be used as a hydrophobic barrier to direct the flow path or isolate reaction zones, which is easy to operate without external units.

Electrophoresis 2009, 30, 1497–1500

Microvalve-actuated Precise Control of Droplets

We designed the integrated microvalve-actuated microdevice, which enabled the manipulation of individual droplet precisely. The droplets with different size and composition, or even the fusion can be produced flexibly which might be useful for high throughput screening applications.

Lab on Chip,2009,9,1340–1343